![]() ![]() ![]() Toxicity is typically divided into stages, but this may not work perfectly in every patient (especially in patients who ingested several doses of acetaminophen over time). ![]() Inducers of CYP2E1 (increase metabolism of acetaminophen into toxic NAPQI):.Zidovudine, trimethoprim/sulfamethoxazole.Decreased hepatic capacity for glucuronidation:.( 29605069)įactors that increase the risk of acetaminophen toxicity “Alcohol-Tylenol syndrome” – Ongoing use of several grams of acetaminophen daily along with alcohol.NyQuil and related products that combine acetaminophen with antihistamines). Patients with cold/flu symptoms who take acetaminophen along with combination cold medications (e.g.Patients with chronic pain who take acetaminophen along with combination analgesics (e.g.Peak absorption of immediate-release tablets usually occurs within 2-4 hours of ingestion.( 29605069, 34053705) Ingestions > 30 grams are classified as massive this may require more aggressive therapy. ( 31786822) However, this varies considerably between patients. Acetaminophen doses above > 10 grams or >200 mg/kg (whichever is less) may be toxic. ![]()
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